Proteins and peptides are the working molecules of life, they make up the fundamental machinery that runs most biological processes. These essential components form the backbone of countless biological functions, driving the intricate mechanisms that sustain life. Peptides: A New Frontier in Human Health and Agriculture As research progresses in the world of proteins and peptides, we uncover their immense potential in both human health and agriculture. This emerging field promises groundbreaking advancements in how we approach medicine and crop protection. We're a proud industry partner to The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS). This is a national research centre funded through the Australian Research Council’s Centres of Excellence scheme. Their vision is to discover new proteins and peptides from Australia’s diverse flora and fauna, decode their biological functions, and develop new proteins and peptides to address challenges in health, agriculture and industry.

Peptides are molecules that plants use to protect themselves from insects. These remarkable compounds serve as a natural defense mechanism, allowing plants to ward off potential threats and maintain their health. The role of peptides in plant protection is a fascinating area of study, revealing the intricate ways in which nature has evolved to ensure survival. The diversity of peptides found in plants is truly astounding. There are many types of these protective molecules, each with its own unique properties and functions. This variety showcases the complexity of plant defense systems and the evolutionary arms race between plants and their insect predators. Interestingly, the Australian bush provides a wealth of success stories in the ongoing battle between plants and insects. This unique ecosystem has given rise to numerous plant species that have developed highly effective peptide-based defense mechanisms. These natural solutions offer valuable insights for researchers and could potentially inspire new approaches to crop protection and pest management.

Sero-X is approved for use in cotton against Helicoverpa spp., Silverleaf whitefly (biotype b) (Bemisia tabaci), and Green mirid (Creontiades dilutus). It offers control through three distinct modes of action: Anti-feedant Effect: Sero-X reduces plant damage by causing starvation and lowering the overall viability of target pests, such as Helicoverpa spp., Silverleaf whitefly (biotype b), and Green mirid (Creontiades dilutus). Direct Mortality: The active compounds in Sero-X disrupt the cell membrane walls of the pests, leading to their direct elimination. Oviposition Deterrent: Sero-X modifies the behavior of these insects, negatively impacting their egg-laying activities and reducing future generations. The mode of action of Sero-X's cyclic peptides, known as cyclotides, involves direct interaction with the cell membranes of phytophagous insects, as demonstrated in the research by Barbeta et al. (PNAS 2008, 105, 1221).

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